QBD-Based Approach for Formulation Development of Docetaxel-Loaded Solid Lipid Nanoparticles in Combination with Herbal Extracts for Breast Cancer

Abstract

In line with a Quality by Design approach, this study developed docetaxel-encapsulated solid lipid nanoparticles (SLNs) with herbal extracts for improved breast cancer treatment safety and efficacy. The solvent emulsification and ultrasonication-prepared SLNs are used for increasing the solubility of docetaxel, overcoming chemoresistance, and minimizing toxicity. Proper study of preparation factors helped in achieving better control over the size of the nanoparticles, percentage of encapsulation, as well as release. The optimized nanocarriers possessed stability, high loading of docetaxel, sustained release, and enhanced anticancer effects when conjugated with antitumor herbs. In summary, this work establishes the co-delivery of breast cancer treatment through encapsulating chemotherapeutic drugs with natural compounds using targeted SLNs. Nanoformulation has a positive impact on pharmacotherapy as it leads to an increase in the bioavailability and specificity of tumor tissue and reduces general toxicity. More possibilities can be seen in other chemorefractory cancers and better patient concordance along with therapeutic efficacy achieved through combinational drug delivery. More large-scale production and preclinical studies could pave the way for the clinical application of this integrated strategy using QbD Design nanoparticles in the fight against lethal carcinoma.