The Effect of Periodontitis Treatment on Anti-DSDNA Titer in Patients with Systemic Lupus Erythematosus

Abstract

Aim: Systemic Lupus Erythematosus (SLE) and periodontitis are both inflammatory diseases. It has been revealed that may be an association exists between them. Inflammation in chronic periodontitis causes gingival erosion and alveolar bone destruction. According to available sources, chronic inflammation due to periodontal disease has a negative effect on Anti-dsDNA as one of the most important laboratory indicators of SLE. The aim of this research is to evaluate the effect of periodontal treatment on Anti-dsDNA titer in patients with SLE.

Materials and methods:  The samples were selected from well controlled patients with SLE . In the initial visit, the laboratory factor “Anti-dsDNA” was recorded from the patients. Patients with periodontal disease were divided into case and control groups by block randomization method. For the case group, scaling was done with an ultrasonic device and oral health education was provided to all patients. The patients were asked to return 3 months after the periodontal treatment to evaluate the level of disease activity and the response to periodontal treatment. For data analysis, SPSS 18 program and Mann-Whitney non-parametric test was used.

Results: The average duration of the disease in this study was 6.89 ± 6.56 years. Comparison of the average Anti-dsDNA autoantibody titer before and after treatment in the intervention group considering that there was no normality between the data and there was a statistically significant difference between the average Anti-DsDNA  titer before and after the intervention in the subject group.

Conclusion:  Since the phase 1 of periodontal treatment as a modifiable risk factor has led to a significant change in Anti-dsDNA titer and this antibody is an indicator of disease flare, periodontal treatment is recommended separately from the reactivation of the disease and to promote the disease control.