Advanced Recognizing and Categorizing System for Alzheimer's and Parkinson's Syndromes using CNN Algorithm and Clinical Data

Abstract

Parkinson’s Disease (PD) and Alzheimer’s Disease (AD) are advancing neurodegenerative diseases that impact a large number of individuals globally. This study provides a novel method to identify and categorize individuals in the early stages of PD and AD by analyzing online handwriting structures, leveraging the current progress in Machine Learning (ML) in the medical domain. The research explores multiple data augmentation strategies to address the limited training information available for classifying neuro-degenerative disorders based on behavioral information.  The study used a Convolutional Neural Network (CNN) classification as a foundation model by identifying essential radiomics characteristics from the T1-weighted Magnetic Resonance Imaging (MRI) data. The research explores data augmentation strategies designed explicitly for time-series information, such as online handwriting patterns, instead of standard methods used for hardware-based detection. This approach, with more validation, might assist in distinguishing between difficult instances of AD and PD that have a comparable mild motor and non-motor symptoms.